For example, the female group most frequently suffers from nausea, vomiting and indigestion, and they also most often report pain in the middle of the back and in the jaw. When the age is more advanced, another striking symptom is sudden dyspnea (breathing problems). Seduced by the music that came from the other side of the ocean, heralding a new era in the treatment of cancer, the immunologist at the Hospital Jaguars Depth Chart Barcelona, Manuel Juan, thanks to a sabbatical scholarship from the hospital, left in 2013 to the United States to observe closely the revolutionary therapeutic arsenal that the multinational Novartis, in collaboration with the University of Pennsylvania, were putting together to fight some of the types of cancer haematological with worse prognosis when there is relapse: Acute Lymphoblastic Leukemia (ALL), chronic lymphocytic leukemia, and non-Hodgkin lymphomas.
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In 2017, fruit of the project promoted by Ari, who unfortunately died before seeing how the CAR-T took charge, Hospital Clínic launched the first clinical trial aimed at evaluating the safety and efficacy of its own Chimeric Antigen T-receptor (CART-T) against the CD19 molecule of these leukemias and lymphomas (CAR-T19). It included a dozen patients with lymphoma or acute lymphoblastic leukemia (ALL) who had not responded to conventional treatments. “The CAR-T19 is effective in 85 percent of candidate patients, who are those who do not respond to treatments and have relapsed, but it is also effective in other diseases,” say the experts of the Clinic.
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This trial with its own CAR-T turned Hospital Clínic into one of the few European centers capable of offering this therapy outside commercial development. “Our goal has always been to bring this technology to clinical practice and we have achieved it,” says Julio Delgado, consultant at the Clinic’s Hematology Service.
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“The disease-free survival at two years is about 50 percent,” says the expert, who stresses the importance of this advance “if we take into account that until now in cases of resistant leukemia we could only do one allogeneic transplant of bone marrow, more toxic and with a survival per year that does not exceed 20 percent, “recalls Delgado.
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In addition to effectiveness, a significant advantage of CAR-T over chemotherapy or bone marrow transplantation are the few side effects it presents, although there are two that are serious “and can even lead to death”, the syndrome of cytokine release (CRS) and neurotoxicity. “Now, the challenge, at a clinical level, is to reduce these effects and, at a functional level, that this technique goes to the service portfolio of the Clinic,” Juan and Delgado note.
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At present, the CAR-T platform of the hospital has a staff of 150 specialists from different disciplines, from which 25 patients have already been treated with ALL 20 and five with non-Hodgkin lymphomas (NHL), seven of them pediatric.
The problem is not that doctors do not know how to recognize the symptoms in women, but that by not identifying them it takes more time to ask for Jaguars Depth Chart help and go to an emergency service. The classic pain in the chest that radiates to the left arm, a well-known symptom among the population, is the typical infarction of a man but not in them.