This genetic disease is associated with stress and female hormones associated with the menstrual cycle. This is why the team of the doctor of the Center for Applied Medical Research (CIMA) of the University of Navarra, Cleveland Browns Depth Chart, has investigated several therapies to treat porphyria. Currently, one of them, after good results in the preclinical phase, has already been successfully tested in a trial with eight patients. Projects aimed at the development of earlier diagnoses are also supported by the foundation. Specific, the team of Carlos Camps, of the General Hospital of Valencia, has managed to detect lung cancer in a drop of blood, which opens the way to develop much less invasive and more precise tests than the techniques currently used.
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From HM Hospitales, the Cardiomujer initiative has been promoted, a specialized consultation in female cardiac health coordinated by cardiologist Leticia Fernández-Friera, director of the Cardiac Imaging Unit of HM CIEC. The need for this consultation with a gender perspective is justified by the data: mortality after a first acute myocardial infarction is 20% higher in women, especially in countries such as Spain, according to the Spanish Society of Cardiology.
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The new strategy to face the LLA, called CAR-T (the acronym of the English Chimeric Antigen Receiver T-Cell) supposed a revolutionary change of paradigm: to use the cells of the immune system of the own patient and to reprogram them of genetic form so that they attack selectively to the tumor leaving healthy ones unharmed. It was the first time in the long fight against the disease that “live drugs” were used with the potential to generate antitumor immune surveillance throughout the life of the patient.
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Manuel Juan, Head of the Immunotherapy Section of the Clinic’s Immunology Service and responsible for the center’s Immunotherapy Platform and the Sant Joan de Deu Hospital, was not the only scientist to be trained in the United States about the use and potential of this new technology. Also the hematology or Julio Delgado and pediatric hematologist Susana Rives, from the same team, were trained in the clinical management of CAR-Ts therapy.
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They tried, according to ABC, to explain that the Clínic group was part of the project promoted by the international pharmaceutical division Novartis, “although it was not possible”.
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“When we returned, in 2014, we decided to create our own structure,” says the hematologist. The team from the Barcelona center opened with the construction of a CAR-T immunoreceptor based on an own antibody that had been designed by the Hospital Immunology Service years ago. With this they started the project, although with little financial muscle. A scholarship from the Carlos III Institute to carry out the preclinical phase and little else, the researchers aim.
The Mutua Madrileña Foundation has financed since 2014 the development of a national registry of patients with ventricular assistance waiting for a heart. The registry, coordinated by the cardiologists of the A Cleveland Browns Depth Chart University Hospital, Eduardo Barge and Marisa Crespo, makes it possible to streamline the protocols and redefine the inclusion criteria for patients with emergency 0.